Last edited by Kegore
Wednesday, July 29, 2020 | History

3 edition of Oncogenic adenoviruses. found in the catalog.

Oncogenic adenoviruses.

L. P. Merkow

Oncogenic adenoviruses.

by L. P. Merkow

  • 21 Want to read
  • 10 Currently reading

Published by S. Karger in Basel, New York .
Written in English

    Subjects:
  • Oncogenic viruses,
  • Adenoviruses

  • Edition Notes

    Includes bibliographies.

    StatementGuest editors: L. P. Merkow and M. Slifkin. Contributions: B. C. Casto [and others]
    SeriesProgress in experimental tumor research,, v. 18, Progress in experimental tumor research ;, vol. 18.
    ContributionsSlifkin, Michael A., joint author., Casto, Bruce C.
    Classifications
    LC ClassificationsRC254 .A335 vol. 18, RC268.57 .A335 vol. 18
    The Physical Object
    Paginationx, 312 p.
    Number of Pages312
    ID Numbers
    Open LibraryOL5459597M
    LC Control Number73162062

    Structural and biochemical stu­ dies dominated the early years. In , some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans­ formed and tumor cell systems.   Abstracts of papers presented at the Tumor Virus Meeting on SV40, Polyoma, and Adenoviruses, August Aug

    Adenovirus, any virus belonging to the family Adenoviridae. This group of viruses was discovered in the s and includes 6 genera and 47 species (formerly referred to as serotypes) that cause sore throat and fever in humans, hepatitis in dogs, and several diseases in fowl, mice, cattle, pigs, and virus particle lacks an outer envelope; is spheroidal, about 80 nm (1 nm = ALTHOUGH human adenovirus types 3 (ref. 1), 7 (ref. 2), 12 (ref. 3), 18 (ref. 4), 14, 16, 21 (unpublished work of M. Pina and M. Green) and 31 (ref. 5) have been shown to be oncogenic in hamsters.

    In book: Oncolytic Viruses, pp Adenoviruses (Ad) are efficient vehicles for gene delivery in vitro and in vivo. Enhancement by Thymectomy of Tumor Formation by Oncogenic Adenoviruses. Get this from a library! The Molecular Repertoire of Adenoviruses III: Biology and Pathogenesis. [Walter Doerfler; P Böhm] -- For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of .


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Oncogenic adenoviruses by L. P. Merkow Download PDF EPUB FB2

OCLC Number: Description: x, pages illustrations 25 cm. Contents: Structure and function Oncogenic adenoviruses. book virion proteins of adenoviruses --Bovine adenoviruses --Simian adenoviruses --Chicken embryo lethal orphan virus (CELO) --PARA-adenoviruses --Sex-related resistance in hamsters to adenovirus oncogenesis --Biologic parameters of adenovirus transformation --Alterations in hamster cell.

Given the fact that virtually all DNA tumor viruses including adenoviruses induce chromosomal damage and other mutations in the host cell genome (14, 23, 37), we next asked whether the oncogenic hit may be caused by mutations that accumulate during the transient presence of the viral E1A and E4 : Michael Nevels, Birgitt Täuber, Thilo Spruss, Hans Wolf, Thomas Dobner.

Several nonhuman adenoviruses derived from bovine, simian, porcine, ovine, murine, and canine sources have been used as backbone to develop E1-deleted vectors for gene therapy or vaccine purposes (reviewed in Lopez-Gordo et al.).

62 Table 1 summarizes the main nonhuman adenoviruses used as vectors and the corresponding cell lines. For the majority of nonhuman vectors, specialized. Transforming and Oncogenic Properties of Human Adenoviruses Human adenoviruses (Ads) are small, nonenveloped DNA viruses with linear, double-stranded genomes of about 35 kbp that are associated with a broad range of infections, but are most commonly linked with acute infections of the upper respiratory and gastrointestinal tracts.

Adenovirus 12 (Ad12) (Huie) (highly oncogenic group A) readily induces tumors in newborn rodents. Since Ad12 is isolated from human fecal samples, we investigated whether it plays a role in the etiology of human gastrointestinal cancer.

If Ad12 is a causal Cited by:   Adenovirus is known to be oncogenic in rodents but not in humans. Adenovirus has been associated with both sporadic and epidemic disease and, with regard to infections among military recruits, who were routinely immunized against types 4 and 7 from until the cessation of vaccine production in Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens.

After the first volume on virion and structure, viral replication and host-cell interaction this second volume deals with the immune system, oncogenesis and gene therapy. Adenoviruses are frequently used as experimental vectors for gene therapy and cancer therapy, and have been used as vectors for recombinant vaccines.

They also received a brief flurry of interest shortly after their discovery, because of their oncogenic behavior in experimentally infected laboratory rodents. Adenoviruses (members of the family Adenoviridae) are medium-sized (90– nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome.

Their name derives from their initial isolation from human adenoids in They have a broad range of vertebrate hosts; in humans, more than 50 distinct adenoviral serotypes have been.

On the other hand, HAdV subgroup B are weakly oncogenic, and finally HAdV subgroups C, E, and F are not known to be oncogenic. However, it has been shown that the cells transformed by non-oncogenic HAdV can cause tumors in immunocompromised host, indicative of the host immune system rejecting those transformed by the non-oncogenic adenoviruses.

A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology.

I.W. Jennings M.R.C.V.S., in Vitamins in Endocrine Metabolism, 2 Viral carcinogens. Oncogenic viruses belong to both major viral groups. Examples of DNA viruses include the infective agent of the human wart, adenoviruses, the Shope rabbit papilloma.

Adenovirus 12 (Ad12) (Huie) (highly oncogenic group A) readily induces tumors in newborn rodents. Since Ad12 is isolated from human fecal samples, we investigated whether it plays a role in the etiology of human gastrointestinal cancer.

If Ad12 is a causal agent of human cancer, then human tumors should contain Ad12 transforming genes, as indicated by studies of cells transformed in vitro and. Certain adenoviruses are strongly oncogenic; adenovirus ty 18 and 31 act in this manner in suckling hamsters. These adenovirus-induced tumours contain a T antigen which is evidence of a causal relationship between the adenovirus and the tumour.

The T antigen can be detected only with an antiserum from a tumour-bearing hamster and does. An oncovirus is a virus that can cause term originated from studies of acutely transforming retroviruses in the –60s, when the term "oncornaviruses" was used to denote their RNA virus origin.

With the letters "RNA" removed, it now refers to any virus with a DNA or RNA genome causing cancer and is synonymous with "tumor virus" or "cancer virus". Although adenoviruses have been established for quite some time as one of the most pliable tools to study the molecular biology of mammalian cells, rapid progress continues to be made with this virus system.

The adenoviral genome introduced into the nucleus of cells as a Trojan Horse, as it were, is now facili­ tating investigators to uncover details of cellular mechanisms.

variation in the oncogenic potential of human adenoviruses carrying a defective sv40 genome (para) Fred Rapp, Maryann Jerkofsky, Joseph L. Melnick, and Barnet Levy From the Department of Virology and Epidemiology, Baylor University College of Medicine, and the University of Texas Dental Science Institute, Houston, Texas The Molecular Biology of Adenoviruses 2: 30 Years of Adenovirus Research (Current Topics in Microbiology and Immunology) [Walter Doerfler] on *FREE* shipping on qualifying offers.

The data summarized in this chapter show that morphological transformation and oncogenesis by adenoviruses are brought about by the coordinated activity of regions E1A and E1B. 2. Adenoviruses (Ad) General Biology and Implications for Virotherapy.

Adenoviruses are non-enveloped viruses with an icosahedral capsid that contains a double stranded linear DNA of about 36 kb. Adenoviruses are found across all vertebrates, from fishes to. Purchase The Molecular Biology of Viruses - 1st Edition. Print Book & E-Book.

ISBN. In addition to the well-studied E1A and E1B oncogenes, group C adenoviruses harbor a third oncogene, E4orf6, which functions in some respects similarly to the E1B oncogene. Although adenoviruses are not known to be associated with tumorigenesis in humans, some human adenovirus serotypes can directly induce tumors in rats or hamsters, and all.Oncogenesis.- Modulation of Oncogenic Transformation by the Human Adenovirus E1A C-Terminal Region.- Cell Transformation by Human Adenoviruses.- Tumorigenesis by Adenovirus Type 12 in Newborn Syrian Hamsters.- E1A-Based Determinants of Oncogenicity in Human Adenovirus Groups A and C.- Gene Therapy.- Replicating Adenoviruses in Cancer Therapy.-Price: $Book: All Authors / Contributors: Ludwik Gross.

Find more information about: ISBN: --Oncogenic potency of adenoviruses --Burkitt Lymphoma in African children and the Epstein-Barr virus. with a note on infectious mononucleosis --The "slow virus diseases" and their possible relation to cancer and leukemia.